Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential

Phosphodiesterase 4D inhibitors limit prostate cancer growth potential.

UNLABELLED Phosphodiesterase 4D (PDE4D) has recently been implicated as a proliferation-promoting factor in prostate cancer and is overexpressed in human prostate carcinoma. However, the effects of PDE4D inhibition using pharmacologic inhibitors have not been examined in prostate cancer. These studies examined the effects of selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as anti-prostat...

Oncogenes and Tumor Suppressors Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential

Phosphodiesterase 4D (PDE4D) has recently been implicated as a proliferation-promoting factor in prostate cancer and is overexpressed in human prostate carcinoma. However, the effects of PDE4D inhibition using pharmacologic inhibitors have not been examined in prostate cancer. These studies examined the effects of selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as anti–prostate cancer th...

1 Phosphodiesterase 4 D Inhibitors Limit Prostate Cancer Growth Potential

Phosphodiesterase 4D (PDE4D) has recently been implicated as a proliferationpromoting factor in prostate cancer and is over-expressed in human prostate carcinoma. However, the effects of PDE4D inhibition using pharmacological inhibitors have not been examined in prostate cancer. These studies examined the effects of selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as anti-prostate cancer ...

Phosphodiesterase-5 Inhibitors: Potential Nephroprotective Agents

Zaher Armaly1 and Zaid Abassi2,3* 1Departmentof Nephrology, EMMS Nazareth–The Nazareth Hospital, Nazareth and Galilee Medical School-Bar Ilan University, Safed, Israel 2Research Unit, Rambam Health Care Campus Haifa, Israel 3Department of Physiology, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel *Corresponding author: Zaid Abassi, Department of Physiology...

Anti-cancer Role of Phosphodiesterase-5 Inhibitors